منابع مشابه
Molecular Biology of Wilm's Tumour
at an early age. Furthermore, a genetic predisposition to develop the tumour is associated with aniridia, genitourinary abnormalities and mental retardation (the WAGR syndrome) (1). Children with this rare syndrome typically carry a germline deletion involving band p13 on one of the two (parentally-derived) chromosome 11 homologues (2). The inherited 11 p deletion in WAGR and hereditary Wilms' ...
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Tumour is a sum of genetic errors with constantly proliferating cells. Development of cancer requires altered mechanism in just one cell resulting in unlimited replication of that cell. Inspite of several genetic insults that occur there are few cells which turn neoplastic. Thus, suggesting of a very powerful protective mechanism at work. p53, a tumour suppressor gene, is cancer prophylactic fo...
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Sulfated polysaccharides can act not only as anticoagulants but also as tumour inhibitors. Recent studies suggest that sulfated polysaccharides could affect tumour cells directly. Sulfated polysaccharides could inhibit the metastasis and proliferation of tumour cells by binding to growth factors and cell adhesion molecules. Moreover, sulfated polysaccharides could inhibit heparanase, which clea...
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Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...
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Proteoglycans, key molecular effectors of cell surface and pericellular microenvironments, perform multiple functions in cancer and angiogenesis by virtue of their polyhedric nature and their ability to interact with both ligands and receptors that regulate neoplastic growth and neovascularization. Some proteoglycans such as perlecan, have pro- and anti-angiogenic activities, whereas other prot...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2014
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nou082